The imply constant condition volume of distribution (Vss) for sildenafil is one zero five L, indicating distribution to the tissues. Sildenafil and its main circulating N-desmethyl metabolite are each about 96% bound to plasma proteins. Protein binding is impartial of full drug concentrations.

Physicians ought to suggest sufferers to stop taking PDE5 inhibitors, such as VIAGRA, and seek out prompt professional medical notice during the event of sudden lessen or lack of hearing. These events, which may be accompanied by tinnitus and dizziness, have been noted in temporal Affiliation on the consumption of PDE5 inhibitors, together with VIAGRA.

The protection of VIAGRA is unfamiliar in clients with bleeding Ailments and clients with active peptic ulceration.

Denne potensmedisinen skal kun brukes av personen den er foreskrevet til, og du bør derfor ikke gi medisinen til noen andre, selv om de kanskje har de samme symptomene på ereksjonssvikt som det du har. Dette legemidlet vil bare hjelpe deg med å fileå ereksjon hvis du er seksuelt stimulert.

Legemidlet skal ikke tas sammen med grapefrukt eller grapefruktjuice da dette kan gi angina og hjerteinfarkt. Medisinen skal heller ikke tas samtidig som andre orale eller lokale behandlinger mot erektil dysfunksjon.

Permanent harm to the penis could occur if priapism is just not addressed swiftly. Cease getting sildenafil and acquire emergency assistance When you have any of the subsequent signs or symptoms of priapism.

Never acquire sildenafil Unless of course it's been prescribed for you by a Health care provider. Get it as prescribed.

Denne potenspillen er en behandling for menn som lider av erektil dysfunksjon (impotens) det vil si, manglende evne til å oppnå eller opprettholde en ereksjon som varer lenge nok for tilfredsstillende seksuell nytelse.

Medical professionals ought to inform people to not get VIAGRA with other PDE5 inhibitors which include REVATIO or other pulmonary arterial hypertension (PAH) treatment plans that contains sildenafil.

Using sildenafil and an αone blocker (normally prescribed for hypertension or for urologic conditions, for instance benign prostatic hypertrophy) concurrently may bring about minimal blood pressure level, but this outcome does not occur if they are taken at least 4 website several hours aside.[29]

†Irregular Eyesight: Moderate to average in severity and transient, predominantly colour tinge to eyesight, but also elevated sensitivity to light, or blurred eyesight.

PDE3 is associated answerable for cardiac contractility. Sildenafil is barely about 10-fold as potent for PDE5 compared to PDE6, an enzyme present in the retina that's associated with the phototransduction pathway in the retina. This reduced selectivity is regarded as the basis for abnormalities connected with colour eyesight [see Pharmacodynamics].

If you take sildenafil When you consume a high-Fats food, like a burger and fries, it could just take longer to start Operating.

Determined by animal information, VIAGRA isn't predicted to increase the possibility of adverse developmental outcomes in individuals.